what is the difference between myo inositol and d-chiro inositol

Dr.Muhammad imran(Rph) B.sc,Pharm.D,M.phil(pharmaceutics)
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chiro inositol and myo inositol
CharacteristicMyo-inositolD-chiro-inositol
     StructureCyclohexane with 6 hydroxyl groupsStereoisomer of myo-inositol
Natural abundanceMore common in natureLess common in nature
Insulin sensitivityImproves insulin sensitivityMore potent in improving insulin sensitivity
Ovarian functionSupports follicle developmentSupports ovulation
PCOS treatmentPrimary inositol usedOften used in combination with myo-inositol
Dosage in supplementsUsually higher dosesUsually lower doses
Conversion in bodyCan be converted to d-chiro-inositolCannot be converted to myo-inositol

Key differences:

  1. Structure: Stereoisomers with different hydroxyl group orientations
  2. Abundance: Myo-inositol is more common in nature
  3. Potency: D-chiro-inositol is more potent in improving insulin sensitivity
  4. Function: Myo-inositol supports follicle development; d-chiro-inositol supports ovulation
  5. PCOS treatment: Often used in combination, with myo-inositol as the primary form
  6. Dosage: Myo-inositol typically used in higher doses than d-chiro-inositol
  7. Conversion: Body can convert myo-inositol to d-chiro-inositol, but not vice versa

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